Quantification analysis of splice signal sequences. Exon skipping in beta-globin gene of thalassemia.

Article

Quantification analysis of splice signal sequences. Exon skipping in beta-globin gene of thalassemia.

Nucleic acids symposium series - 1 Jan 1993

Iida Y

Abstract excerpt

Nucleotide sequences of human beta-globin and its mutant genes were analyzed by quantification method. In the mutant, a GT-->AT change occurs at the 5'-splice site of the second intron, causing skipping of the whole second exon during RNA splicing. A mechanism of exon skipping was proposed on the...

Topics

Base Sequence
DNA
Exons
Globins
Humans
Introns
Molecular Sequence Data
Mutation
RNA Precursors
RNA Splicing
RNA, Messenger
Thalassemia

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