Quantification analysis of human alpha-globin gene. Mutation in 5'-splice junction sequence and alpha-thalassemia.

Article

Quantification analysis of human alpha-globin gene. Mutation in 5'-splice junction sequence and alpha-thalassemia.

Nucleic acids symposium series - 1 Jan 1990

Iida Y

Abstract excerpt

Nucleotide sequence of the exon-intron junction in human alpha-globin gene was analyzed by quantification method proposed previously. Using sample score of 9-nucleotide sequence at 5'-splice site, we examined strength of the splice signal. We further studied a mutant of alpha-thalassemia, where p...

Topics

Base Sequence
Exons
Globins
Humans
Introns
Molecular Sequence Data
Mutation
RNA Precursors
RNA Splicing
Thalassemia

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