Article
Exon repetition: a major pathway for processing mRNA of some genes is allele-specific.
Nucleic acids research - 1 Jan 2004
Rigatti Roberto, Jia Jian-Hua, Samani Nilesh J, Eperon Ian C
Abstract excerpt
Exon repetition describes the presence of tandemly repeated exons in mRNA in the absence of duplications in the genome. Its existence challenges our understanding of gene expression, because the linear organization of sequences in apparently normal genes must be subverted during RNA synthesis or processing. It is restricted to a small number of genes in some of which over half of the mRNA contains specific...
Topics
- Alleles
- Animals
- Coenzyme A Ligases
- Exons
- Heterozygote
- Models, Genetic
- Molecular Sequence Data
- Proteins
- RNA Precursors
- RNA Processing, Post-Transcriptional
- RNA Splice Sites
- RNA, Messenger
- Rats
- Rats, Inbred SHR
- Rats, Inbred WKY