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Article

Sequence requirements in different steps of the pre-mRNA splicing reaction: analysis by the RNA modification-exclusion technique.

Molecular and cellular biology - 1 Sept 1990

Lang K M, Keller W

Abstract excerpt

The stepwise assembly of splicing complexes and the subsequent splicing reaction were analyzed by the RNA modification-exclusion technique, which generates the equivalent of a complete set of point mutations in a single reaction. We found that although the sequences surrounding the 5' splice site, the branch point, and the 3' splice site, including the 3' AG, were required for presplicing complex formation,...

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Identifiers

PMID: 2201909
DOI: 10.1128/mcb.10.9.4942-4947.1990
PMCID: PMC361115

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Source receipt: pubmed, retrieved 7 Sept 2026.

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