Article
Tumor necrosis factor gene polymorphisms in ankylosing spondylitis.
Tissue antigens - 1 Apr 1998
Fraile A, Nieto A, Beraún Y, Vinasco J, Matarán L, Martín J
Abstract excerpt
Despite the strength of the association of ankylosing spondylitis (AS) with HLA-B27, other genetic elements could play a possible role in the pathophysiology of AS. In view of its gene location, in the proximity of the HLA-B locus, and biological effects, tumor necrosis factor (TNF) genes are potential candidates for additive susceptibility factors to AS. TNFalpha and TNFbeta genotypes were analyzed by PCR-RFLP...
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