Polymorphism of tumour necrosis factor-alpha (TNF-alpha) at position -308 in relation to ankylosing spondylitis.

doi:10.1111/j.1365-2249.1994.tb06577.x

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Article

Polymorphism of tumour necrosis factor-alpha (TNF-alpha) at position -308 in relation to ankylosing spondylitis.

Clinical and experimental immunology - 1 Jul 1994

Verjans G M, Brinkman B M, Van Doornik C E, Kijlstra A, Verweij C L

Abstract excerpt

In addition to HLA-B27, other genetic factors are thought to be involved in the pathogenesis of ankylosing spondylitis (AS). Because of the localization, in the proximity of the HLA-B locus, and the biological activities of TNF-alpha, we investigated the association between AS and a single base p...

Topics

Alleles
Base Sequence
DNA Primers
Gene Frequency
HLA-B27 Antigen
Humans
Molecular Sequence Data
Polymorphism, Genetic
Spondylitis, Ankylosing
Tumor Necrosis Factor-alpha

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