Article
Restriction fragment length polymorphism of the tumor necrosis factor region in patients with ankylosing spondylitis.
Arthritis and rheumatism - 1 Apr 1991
Verjans G M, van der Linden S M, van Eys G J, de Waal L P, Kijlstra A
Abstract excerpt
Although ankylosing spondylitis (AS) is known to be strongly associated with the class I major histocompatibility complex antigen HLA-B27, B27 is probably not the only genetic factor involved in the pathogenesis of AS. Because of the involvement of tumor necrosis factor (TNF) in cartilage damage...
Topics
- Alleles
- Chi-Square Distribution
- Chromosome Mapping
- DNA Probes
- Gene Frequency
- Genetic Linkage
- HLA-B27 Antigen
- Humans
- Phenotype
- Polymorphism, Restriction Fragment Length
- Spondylitis, Ankylosing
- Tumor Necrosis Factor-alpha