Article
Restriction fragment length polymorphism of the tumor necrosis factor region in patients with ankylosing spondylitis.
Arthritis and rheumatism - 1 Apr 1991
Verjans G M, van der Linden S M, van Eys G J, de Waal L P, Kijlstra A
Abstract excerpt
Although ankylosing spondylitis (AS) is known to be strongly associated with the class I major histocompatibility complex antigen HLA-B27, B27 is probably not the only genetic factor involved in the pathogenesis of AS. Because of the involvement of tumor necrosis factor (TNF) in cartilage damage and the localization of the TNF genes in the proximity of the HLA-B locus, we investigated the association between AS...
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