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Radiosensitivity, apoptosis and repair of DNA double-strand breaks in radiation-sensitive Chinese hamster ovary cell mutants treated at different dose rates.

Radiation research - 1 Dec 1996

Hu Q, Hill R P

Abstract excerpt

The relationship of cell survival to induction and repair of DNA double-strand breaks (DSBs), as assessed by the neutral comet assay, was studied in two pairs of CHO cell lines, repair-deficient mutants xrs-5-11 and V3, and their respective parent lines K-1 and AA8, treated at two dose rates, 10.5 and 0.09 Gy/min. A marked difference in cell survival after irradiation was found between each pair of lines. For...

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PMID: 8955713

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