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Article

p53 null mutations are associated with a telomerase negative phenotype in ovarian carcinoma.

Cancer biology & therapy - 1 Jan 2000

Sood Anil K, Coffin Jeremy, Jabbari Sarvenaz, Buller Richard E, Hendrix Mary J C, Klingelhutz Al

Abstract excerpt

Telomerase activation and p53 dysfunction are important events in the development and progression of most cancers including ovarian cancer. However, many cancer cell lines and human tumors have been shown to lack telomerase, and maintain telomerase through the ALT (alternative lengthening of telomeres). It is not known whether specific types of p53 mutations are correlated with telomerase activity in human...

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Identifiers

PMID: 12496479
DOI: 10.4161/cbt.1.5.167

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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