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Article

Effects of mutations in residues near the active site of human immunodeficiency virus type 1 integrase on specific enzyme-substrate interactions.

Journal of virology - 1 Jun 1998

Gerton J L, Ohgi S, Olsen M, DeRisi J, Brown P O

Abstract excerpt

The phylogenetically conserved catalytic core domain of human immunodeficiency virus type 1 (HIV-1) integrase contains elements necessary for specific recognition of viral and target DNA features. In order to identify specific amino acids that determine substrate specificity, we mutagenized phylo...

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Identifiers

PMID: 9573274
DOI: 10.1128/JVI.72.6.5046-5055.1998
PMCID: PMC110067

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-9573274-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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