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Article

Biochemical and random mutagenesis analysis of the region carrying the catalytic E152 amino acid of HIV-1 integrase.

Nucleic acids research - 1 Jan 2004

Calmels C, de Soultrait V Richard, Caumont A, Desjobert C, Faure A, Fournier M, Tarrago-Litvak L, Parissi V

Abstract excerpt

HIV-1 integrase (IN) catalyzes the integration of the proviral DNA into the cellular genome. The catalytic triad D64, D116 and E152 of HIV-1 IN is involved in the reaction mechanism and the DNA binding. Since the integration and substrate binding processes are not yet exactly known, we studied the role of amino acids localized in the catalytic site. We focused our interest on the V151E152S153 region. We generated...

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Identifiers

PMID: 14999095
DOI: 10.1093/nar/gkh298
PMCID: PMC390286

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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