Article
The catalytic domain of human immunodeficiency virus integrase: ordered active site in the F185H mutant.
FEBS letters - 2 Dec 1996
Bujacz G, Alexandratos J, Qing Z L, Clément-Mella C, Wlodawer A
Abstract excerpt
We solved the structure and traced the complete active site of the catalytic domain of the human immunodeficiency virus type 1 integrase (HIV-1 IN) with the F185H mutation. The only previously available crystal structure, the F185K mutant of this domain, lacks one of the catalytically important residues, E152, located in a stretch of 12 disordered residues [Dyda et al. (1994) Science 266, 1981-1986]. It is clear,...
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