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Article

Analysis of mutations in the integration function of Moloney murine leukemia virus: effects on DNA binding and cutting.

Journal of virology - 1 Oct 1990

Roth M J, Schwartzberg P, Tanese N, Goff S P

Abstract excerpt

The 3' terminus of the pol gene of Moloney murine leukemia virus encodes the integration (IN) protein, required for the establishment of the integrated provirus. A series of six linker insertion mutations and two single-base substitutions were generated within the region encoding the IN protein. Mutations were initially generated within an Escherichia coli plasmid expressing the IN protein, and the resulting...

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Identifiers

PMID: 2204722
DOI: 10.1128/JVI.64.10.4709-4717.1990
PMCID: PMC247957

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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