Genetic and host factors for dementia in Down's syndrome.

Abstract excerpt

BACKGROUND: The high risk for dementia in adults with Down's syndrome has been attributed to triplication and overexpression of the gene for amyloid precursor protein (APP). But the wide variation in age at onset must be due to other risk factors. AIMS: To identify factors which influence age at onset of dementia in Down's syndrome. METHOD: Studies of factors which influence formation of beta-amyloid (Abeta) were...

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