The thyroid hormone receptor variant alpha2 is a weak antagonist because it is deficient in interactions with nuclear receptor corepressors.

doi:10.1210/endo.139.5.6011

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Article

The thyroid hormone receptor variant alpha2 is a weak antagonist because it is deficient in interactions with nuclear receptor corepressors.

Endocrinology - 1 May 1998

Tagami T, Kopp P, Johnson W, Arseven O K, Jameson J L

Abstract excerpt

The thyroid hormone receptor splice variant, alpha2, is unable to bind thyroid hormone (T3) and has been proposed to function as an endogenous inhibitor of T3 action. In this report, we examined further the DNA sequence requirements for alpha2 binding to thyroid hormone response elements (TREs) i...

Topics

Binding Sites
DNA
Dimerization
Humans
Kinetics
Mutation
Promoter Regions, Genetic
RNA Splicing
Receptors, Retinoic Acid
Receptors, Thyroid Hormone
Regulatory Sequences, Nucleic Acid
Repressor Proteins
Retinoid X Receptors
Transcription Factors
Transfection
Triiodothyronine

Source

Open in PubMed

Identifiers

PMID: 9564869
DOI: 10.1210/endo.139.5.6011

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9564869-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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