Article
Regulation of E-cadherin-mediated adhesion in Langerhans cell-like dendritic cells by inflammatory mediators that mobilize Langerhans cells in vivo.
Journal of immunology (Baltimore, Md. : 1950) - 15 Apr 1998
Jakob T, Udey M C
Abstract excerpt
Adhesion of Langerhans cells (LC) to keratinocytes is mediated by E-cadherin. IL-1, TNF-alpha, and LPS mobilize LC from epidermis and presumably attenuate LC-keratinocyte adhesion. To determine whether these mediators modulated LC E-cadherin-dependent adhesion directly, we characterized their eff...
Topics
- Animals
- Antibodies, Monoclonal
- Antigens, Surface
- Cadherins
- Cell Adhesion
- Cell Aggregation
- Cells, Cultured
- Cytokines
- Inflammation Mediators
- Interleukin-1
- Langerhans Cells
- Lipopolysaccharides
- Mice
- Phenotype
- RNA, Messenger
- Tumor Necrosis Factor-alpha