Article
Migration and maturation of Langerhans cells in skin transplants and explants.
The Journal of experimental medicine - 1 Nov 1990
Larsen C P, Steinman R M, Witmer-Pack M, Hankins D F, Morris P J, Austyn J M
Abstract excerpt
The behavior of Langerhans cells (LC) has been examined after skin transplantation and in an organ culture system. Within 24 h (and even within 4 h of culture), LC in epidermal sheets from allografts, isografts, and explants dramatically increased in size and expression of major histocompatibility complex class II molecules, and their numbers were markedly decreased. Using a new procedure, dermal sheets were then...
Topics
- Animals
- Cell Differentiation
- Cell Movement
- Epidermal Cells
- Fluorescent Antibody Technique
- Histocompatibility Antigens Class II
- Immunohistochemistry
- Langerhans Cells
- Male
- Mice
- Phenotype