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Langerhans cell maturation is accompanied by induction of N‐cadherin and the transcriptional regulators of epithelial–mesenchymal transition ZEB1/2

28 Oct 2013

Abstract excerpt

Langerhans cells (LCs) are a unique subset of dendritic cells (DCs) that express epithelial adhesion molecules, allowing them to form contacts with epithelial cells and reside in epidermal/epithelial tissues. The dynamic regulation of epithelial adhesion plays a decisive role in the life cycle of LCs. It controls whether LCs remain immature and sessile within the epidermis or mature and egress to initiate immune...

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PMID: 24165969
DOI: 10.1002/eji.201343681

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