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Article

Cancer-associated epithelial cell adhesion molecule (EpCAM; CD326) enables epidermal Langerhans cell motility and migration in vivo.

Proceedings of the National Academy of Sciences of the United States of America - 10 Apr 2012

Gaiser Maria R, Lämmermann Tim, Feng Xu, Igyarto Botond Z, Kaplan Daniel H, Tessarollo Lino, Germain Ronald N, Udey Mark C

Abstract excerpt

After activation, Langerhans cells (LC), a distinct subpopulation of epidermis-resident dendritic cells, migrate from skin to lymph nodes where they regulate the magnitude and quality of immune responses initiated by epicutaneously applied antigens. Modulation of LC-keratinocyte adhesion is likely to be central to regulation of LC migration. LC express high levels of epithelial cell adhesion molecule (EpCAM;...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22411813
DOI: 10.1073/pnas.1117674109
PMCID: PMC3326512

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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