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Mutations in Rotavirus Nonstructural Glycoprotein NSP4 Are Associated with Altered Virus Virulence

1 May 1998

Abstract excerpt

Rotaviruses are major pathogens causing life-threatening dehydrating gastroenteritis in children and animals. One of the nonstructural proteins, NSP4 (encoded by gene 10), is a transmembrane, endoplasmic reticulum-specific glycoprotein. Recently, our laboratory has shown that NSP4 causes diarrhea in 6- to 10-day-old mice by functioning as an enterotoxin. To confirm the role of NSP4 in rotavirus pathogenesis, we...

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Identifiers

PMID: 9557647
DOI: 10.1128/jvi.72.5.3666-3672.1998

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Mutations in Rotavirus Nonstructural Glycoprotein NSP4 Are Associated with Altered Virus VirulencePMID 9557647Read ↗

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