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Article

NSP4 Gene Analysis of Rotaviruses Recovered from Infected Children with and without Diarrhea

1 Dec 2000

Abstract excerpt

The transmembrane glycoprotein NSP4 functions as a viral enterotoxin capable of inducing diarrhea in young mice. It has been suggested that NSP4 may be a key determinant of rotavirus pathogenicity and a target for vaccine development. Twenty two G1P[6] rotaviruses from babies with and without diarrhea were comparatively analyzed along with reference strains and another 22 Taiwanese human rotaviruses of G and P...

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PMID: 11101582
DOI: 10.1128/jcm.38.12.4471-4477.2000

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