Article
Diarrhea induction by rotavirus NSP4 in the homologous mouse model system.
Virology - 30 Sept 1999
Horie Y, Nakagomi O, Koshimura Y, Nakagomi T, Suzuki Y, Oka T, Sasaki S, Matsuda Y, Watanabe S
Abstract excerpt
Comparison of the NSP4 amino acid sequences from 31 strains of mammalian rotaviruses revealed the presence of four distinct NSP4 alleles; i.e., the Wa, KUN, AU-1, and EW alleles. The EW allele consists only of NSP4s from murine rotavirus strains and is divergent from other NSP4 alleles from the evolutionary perspective. There have been conflicting reports regarding the enterotoxigenic activity of NSP4 in the...
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