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Article

Amino Acid Substitutions in Positions 385 and 393 of the Hydrophobic Region of VP4 May Be Associated with Rotavirus Attenuation and Cell Culture Adaptation.

Viruses - 7 Apr 2020

Guo Yusheng, Wentworth David E, Stucker Karla M, Halpin Rebecca A, Lam Ham Ching, Marthaler Douglas, Saif Linda J, Vlasova Anastasia N

Abstract excerpt

Rotaviruses (RVs) are the leading cause of the acute viral gastroenteritis in young children and livestock animals worldwide. Although live attenuated vaccines have been applied to control RV infection for many years, the underlying mechanisms of RV attenuation following cell culture adaption are unknown. To study these mechanisms at the genomic level, we have sequenced and conducted a comparative analysis of two...

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Identifiers

PMID: 32272747
DOI: 10.3390/v12040408
PMCID: PMC7232350

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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