Article
Mutations selected in rotavirus enterotoxin NSP4 depend on the context of its expression.
Virology - 15 Sept 2000
Mohan K V, Dermody T S, Atreya C D
Abstract excerpt
The rotavirus NSP4 protein is cytotoxic when transiently expressed in cells and is capable of inducing secretory diarrhea in neonatal mice. NSP4 consists of 175 amino acids, and sequences important for its toxic effects have been mapped to the carboxy-terminal half of the protein. In this report, we compared NSP4-encoding nucleotide sequences recovered from cell lines engineered to express NSP4 from human...
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