Article
Differential in vivo activities of bovine growth hormone analogues.
Transgenic research - 1 Jan 1998
Kopchick J, Chen X Z, Li Y, Steger R W, Yun J S, Wagner T E, Bartke A
Abstract excerpt
In rodents, bovine (b) growth hormone (GH) binds only to GH receptors, while human (h) GH binds to both GH and PRL receptors. The phenotypic consequences of expression of bGH and hGH in transgenic mice are different and, in some cases, opposite. In the present study, site-directed in vitro mutagenesis of the bGH gene was used systematically to eliminate its differences from hGH at one, two, three or four...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.