Article
Glomerulosclerosis and body growth are mediated by different portions of bovine growth hormone. Studies in transgenic mice.
Laboratory investigation; a journal of technical methods and pathology - 1 Jan 1993
Yang C W, Striker L J, Pesce C, Chen W Y, Peten E P, Elliot S, Doi T, Kopchick J J, Striker G E
Abstract excerpt
BACKGROUND: Mice transgenic for bovine growth hormone (bGH) gene have increased body weight and severe glomerulosclerosis leading to death in uremia. EXPERIMENTAL DESIGN: The aim of this study was to determine if body growth and glomerulosclerosis were mediated by different bGH regions. Amino aci...
Topics
- Animals
- Blood Glucose
- Body Weight
- Cattle
- Female
- Fluorescent Antibody Technique
- Glomerular Mesangium
- Glomerulosclerosis, Focal Segmental
- Growth Hormone
- Insulin-Like Growth Factor I
- Kidney Glomerulus