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Article

Glomerulosclerosis and body growth are mediated by different portions of bovine growth hormone. Studies in transgenic mice.

Laboratory investigation; a journal of technical methods and pathology - 1 Jan 1993

Yang C W, Striker L J, Pesce C, Chen W Y, Peten E P, Elliot S, Doi T, Kopchick J J, Striker G E

Abstract excerpt

BACKGROUND: Mice transgenic for bovine growth hormone (bGH) gene have increased body weight and severe glomerulosclerosis leading to death in uremia. EXPERIMENTAL DESIGN: The aim of this study was to determine if body growth and glomerulosclerosis were mediated by different bGH regions. Amino acid substitutions in the bGH alpha-helix III were generated, and lines of transgenic mice that expressed these products...

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PMID: 8423678

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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