Article
Evidence that the N-terminus of human growth hormone is involved in expression of its growth promoting, diabetogenic, and insulin-like activities.
Endocrinology - 1 Mar 1992
Towns R, Kostyo J L, Vogel T, Sakal E, Tchelet A, Maher R, Gertler A
Abstract excerpt
Recent work with various point and deletion mutants of human GH (hGH) has suggested that the proximal N-terminal end of the hormone molecule is important for its growth promoting action. This study was conducted to examine the growth promoting, diabetogenic, and insulin-like activities of two N-terminal mutants of hGH, the deletion mutant Des-7 hGH (met8, ala11), and a chimeric mutant of bovine GH (bGH) and hGH...
Topics
- Adipose Tissue
- Animals
- Blood Glucose
- Female
- Growth Hormone
- Insulin
- Male
- Mice
- Mice, Mutant Strains
- Mice, Obese
- Mutation
- Protein Conformation