Article
Effects of an S84E mutation of bovine growth hormone in transgenic mice.
Experimental biology and medicine (Maywood, N.J.) - 1 Mar 2006
Schenck E J H, Brooks C L
Abstract excerpt
The ability of mutant bovine growth hormones (bGH) to serve as either agonist or antagonist has been demonstrated in transgenic mice. We have prepared two transgenic strains of FVB/N mice, one expressing wild-type bGH and a second with a glutamic acid mutation at serine 84 in helix 2. Comparison of their phenotypes to those of nontransgenic littermates indicates that wild-type bGH induces a previously described...
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