Article
Effects of heterologous growth hormones on hypothalamic and pituitary function in transgenic mice.
Neuroendocrinology - 1 Apr 1991
Steger R W, Bartke A, Parkening T A, Collins T, Buonomo F C, Tang K C, Wagner T E, Yun J S
Abstract excerpt
The expression of the mouse metallothionein-I (mMT) promoter/human growth hormone (hGH) fusion gene in transgenic mice leads to female sterility and major alterations in the function of the hypothalamic-adenohypophyseal system. These alterations include increases in median-eminence norepinephrine turnover and plasma LH levels, and a decrease in plasma prolactin levels in intact males, and an increase in...
Topics
- Animals
- Dopamine
- Female
- Genetic Variation
- Growth Hormone
- Hypothalamus
- Luteinizing Hormone
- Male
- Median Eminence
- Metallothionein
- Mice
- Mice, Transgenic