Article
Expression of a mutated bovine growth hormone gene suppresses growth of transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America - 1 Jul 1990
Chen W Y, Wight D C, Wagner T E, Kopchick J J
Abstract excerpt
To determine the importance of the third alpha-helix in bovine growth hormone (bGH) relative to growth-related biological activities, the following experimental approach was used: (i) mutagenesis of helix III of bGH to generate an idealized amphiphilic helix; (ii) in vitro expression analyses of the mutated bGH gene in cultured mouse L cells; (iii) mouse liver membrane binding studies of wild-type and mutated...
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