Article
Fertility of transgenic female mice expressing bovine growth hormone or human growth hormone variant genes.
Biology of reproduction - 1 Jul 1991
Naar E M, Bartke A, Majumdar S S, Buonomo F C, Yun J S, Wagner T E
Abstract excerpt
Although growth hormone (GH) exerts various direct and indirect stimulatory effects on gonadal development and function, excessive levels of GH in acromegalic patients and in transgenic animals are often associated with reproductive disorders. We have examined reproductive performance of transgenic female mice expressing the following hybrid genes: mouse metallothionein-1 (MT)/human placental GH variant (hGH.V),...
Topics
- Animals
- Female
- Fertility
- Gene Expression
- Genetic Variation
- Growth Hormone
- Male
- Metallothionein
- Mice
- Mice, Transgenic
- Phosphoenolpyruvate Carboxykinase (GTP)