Article
Functional analysis of the Numb phosphotyrosine-binding domain using site-directed mutagenesis.
The Journal of biological chemistry - 24 Apr 1998
Yaich L, Ooi J, Park M, Borg J P, Landry C, Bodmer R, Margolis B
Abstract excerpt
The Numb protein is involved in cell fate determination during Drosophila neural development. Numb has a protein domain homologous to the phosphotyrosine-binding domain (PTB) in the adaptor protein Shc. In Shc, this domain interacts with specific phosphotyrosine containing motifs on receptor tyrosine kinases and other signaling molecules. Residues N-terminal to the phosphotyrosine are also crucial for...
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