Article
Coordinate occupancy of AP-1 sites in the vitamin D-responsive and CCAAT box elements by Fos-Jun in the osteocalcin gene: model for phenotype suppression of transcription.
Proceedings of the National Academy of Sciences of the United States of America - 1 Dec 1990
Owen T A, Bortell R, Yocum S A, Smock S L, Zhang M, Abate C, Shalhoub V, Aronin N, Wright K L, van Wijnen A J
Abstract excerpt
Osteocalcin, a bone-specific protein and marker of the mature osteoblast, is expressed only in nonproliferating osteoblasts in a mineralizing extracellular matrix, while type I collagen is expressed in proliferating cells. The nuclear proteins encoded by the c-fos and c-jun protooncogenes are expressed during the proliferation period of osteoblast phenotype development. We present evidence that AP-1 (HeLa...
Topics
- Animals
- Base Sequence
- Calcitriol
- Cell Differentiation
- Cell Division
- Cell Line
- Cells, Cultured
- DNA
- DNA-Binding Proteins
- Genes