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Article

Osteocalcin gene promoter: Unlocking the secrets for regulation of osteoblast growth and differentiation

1 Jan 1998

Abstract excerpt

The bone tissue-specific osteocalcin gene remains one of a few genes that exhibits osteoblast-restricted expression. Over the last decade, characterization of the promoter regulatory elements and complexes of factors that control suppression of the osteocalcin gene in osteoprogenitor cells and transactivation in mature osteoblasts has revealed transcriptional regulatory mechanisms that mediate development of the...

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PMID: 29345833
DOI: 10.1002/(sici)1097-4644(1998)72:30/31+<62::aid-jcb10>3.0.co;2-s

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