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Article

Molecular analysis of CDKN1C and TP53 in sporadic adrenal tumors

1 Aug 2001

Abstract excerpt

OBJECTIVE: To evaluate the roles of the CDKN1C (P57KIP2) gene, which encodes for the cyclin-dependent kinase inhibitor CDNC, and the TP53 tumor suppressor gene in adrenal tumorigenesis, as a means of investigating the molecular basis of sporadic adrenal tumors, which is unknown. DESIGN: Screening for the presence CDKN1C and TP53 mutations and analyzing the expression pattern of CDNC, P53 and its downstream...

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Identifiers

PMID: 11454518
DOI: 10.1530/eje.0.1450207

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