Article
Aberrations of the CHK2 gene are rare in pediatric solid tumors.
International journal of molecular medicine - 1 Jul 2005
Chen Yu Yan, Takita Junko, Tanaka Kiyoshi, Ida Kohmei, Koh Katsuyoshi, Igarashi Takashi, Hanada Ryoji, Kikuchi Akira, Tanaka Yukichi, Toyoda Yasunori, Hayashi Yasuhide
Abstract excerpt
In pediatric solid tumors, such as neuroblastoma (NB), it has been reported that the frequency of TP53 gene alterations is lower than that in adult tumors, suggesting that other tumor suppressor genes may play more important roles in the development of pediatric solid tumors. The CHK2 gene, whose product is a checkpoint kinase that plays a central role in DNA damage response and acts upstream of TP53, has been...
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