Article
Defective global genome repair in XPC mice is associated with skin cancer susceptibility but not with sensitivity to UVB induced erythema and edema.
The Journal of investigative dermatology - 1 Apr 1998
Berg R J, Ruven H J, Sands A T, de Gruijl F R, Mullenders L H
Abstract excerpt
It is generally presumed that xeroderma pigmentosum (XP) patients are extremely sensitive to developing UV erythema, and that they have a more than 1000-fold increased skin cancer risk. Recently established mouse models for XP can be employed to investigate the mechanism of these increased suscep...
Topics
- Animals
- Carcinoma, Squamous Cell
- DNA Repair
- Dose-Response Relationship, Radiation
- Edema
- Erythema
- Genetic Predisposition to Disease
- Genome
- Mice
- Mice, Knockout
- Photosensitivity Disorders
- Pyrimidine Dimers
- Radiation Injuries, Experimental
- Skin Neoplasms
- Transcription, Genetic
- Ultraviolet Rays
- Xeroderma Pigmentosum