Article
The translational activator GCN3 functions downstream from GCN1 and GCN2 in the regulatory pathway that couples GCN4 expression to amino acid availability in Saccharomyces cerevisiae.
Genetics - 1 Nov 1990
Hannig E M, Williams N P, Wek R C, Hinnebusch A G
Abstract excerpt
The GCN4 protein of S. cerevisiae is a transcriptional activator of amino acid biosynthetic genes which are subject to general amino acid control. GCN3, a positive regulator required for increased GCN4 expression in amino acid-starved cells, is thought to function by antagonism of one or more neg...
Topics
- Alleles
- Amino Acid Sequence
- DNA-Binding Proteins
- Eukaryotic Initiation Factor-2B
- Fungal Proteins
- Immunoblotting
- Molecular Sequence Data
- Mutation
- Peptide Elongation Factors
- Phenotype
- Plasmids
- Protein Kinases
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins
- Transcription Factors
- Transformation, Genetic