Article
Mutation screening and identification of a sequence variation in the human ob gene coding region.
Biochemical and biophysical research communications - 27 Mar 1996
Considine R V, Considine E L, Williams C J, Nyce M R, Zhang P, Opentanova I, Ohannesian J P, Kolaczynski J W, Bauer T L, Moore J H, Caro J F
Abstract excerpt
In the present study mRNA from the subcutaneous adipose tissue of 68 obese (defined as a body mass index > or = 27.3 for men and > or = 27.8 for women) and 38 lean subjects was screened for mutations in the ob gene coding region. No mutations in the coding region of the human ob gene were detected using Conformation Sensitive Gel Electrophoresis in 105 subjects. A first base substitution (G to A) was detected in...
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