Article
Susceptibility of transgenic mice expressing human apolipoprotein E to closed head injury: the allele E3 is neuroprotective whereas E4 increases fatalities.
Neuroscience - 1 Jan 2000
Sabo T, Lomnitski L, Nyska A, Beni S, Maronpot R R, Shohami E, Roses A D, Michaelson D M
Abstract excerpt
Apolipoprotein E, the major brain lipid-binding protein, is expressed in humans as three common isoforms (E2, E3 and E4). Previous studies revealed that the allele apolipoprotein E4 is a major genetic risk factor of Alzheimer's disease and that traumatic brain injury is associated with increased...
Topics
- Alleles
- Animals
- Apolipoprotein E4
- Apolipoproteins E
- Brain
- Genetic Predisposition to Disease
- Head Injuries, Closed
- Humans
- Mice
- Mice, Inbred C57BL
- Mice, Transgenic
- Nervous System