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Article

Human apolipoprotein E allele-specific brain expressing transgenic mice.

Neurobiology of aging - 1 Jan 2000

Smith J D, Sikes J, Levin J A

Abstract excerpt

Transgenic mice were created using human apolipoprotein E2, E3, and E4 gene fragments driven by the human glial acidic fibrillary protein (GFAP) promoter. Founders were obtained and progeny were assayed for transgene expression in the brain by RNase protection, immunohistochemistry, and Western blotting, demonstrating robust apolipoprotein E (apoE) brain expression, with human apoE representing up to...

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Source

Identifiers

PMID: 9880043
DOI: 10.1016/s0197-4580(98)00076-1

Genes

GFAP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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