Human apolipoprotein E allele-specific brain expressing transgenic mice.

doi:10.1016/s0197-4580(98)00076-1

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Article

Human apolipoprotein E allele-specific brain expressing transgenic mice.

Neurobiology of aging - 1 Jan 2000

Smith J D, Sikes J, Levin J A

Abstract excerpt

Transgenic mice were created using human apolipoprotein E2, E3, and E4 gene fragments driven by the human glial acidic fibrillary protein (GFAP) promoter. Founders were obtained and progeny were assayed for transgene expression in the brain by RNase protection, immunohistochemistry, and Western b...

Topics

Alleles
Amyloidosis
Animals
Apolipoproteins E
Astrocytes
Brain Chemistry
Cells, Cultured
Cholesterol
Gene Expression
Glial Fibrillary Acidic Protein
Humans
Mice
Mice, Transgenic
Neurons
Promoter Regions, Genetic
Transgenes

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