Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Autonomous growth and hepatocarcinogenesis in transgenic mice expressing the p53 family inhibitor DNp73

4 Nov 2007

Abstract excerpt

p53 family proteins carry on a wide spectrum of biological functions from differentiation, cell cycle arrest, apoptosis and chemosensitivity of tumors. Conversely, N-terminally truncated p73 (DNp73) functions as a potent inhibitor of all these tumor suppressor properties, implicating its participation in malignant transformation and oncogenesis. Several reports indicated considerable up-regulation of DNp73 in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Cancer Research and Treatments
Share to Cell death mechanisms and regulation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 17984115
DOI: 10.1093/carcin/bgm236

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Autonomous growth and hepatocarcinogenesis in transgenic mice expressing the p53 family inhibitor DNp73PMID 17984115Read ↗

DNp73 a matter of cancer: mechanisms and clinical implications.Semantic proximity Read ↗

Biological functions of p53 isoforms through evolution: lessons from animal and cellular models.Semantic proximity Read ↗

p73, a sophisticated p53 family member in the cancer world.Semantic proximity Read ↗

Functional regulation of p73 and p63: development and cancer.Semantic proximity Read ↗

In good times and bad: p73 in cancerSemantic proximity Read ↗

Hepatomegaly in transgenic mice expressing an oncogenic form of beta-catenin.Semantic proximity Read ↗

Targeted deletion of p73 in mice reveals its role in T cell development and lymphomagenesis.Semantic proximity Read ↗

Mechanisms, function and clinical applications of DNp73Semantic proximity Read ↗

Comparative Analysis of P73 and P53 Regulation and Effector FunctionsSemantic proximity Read ↗

Inactivation of retinoblastoma (RB) tumor suppressor by oncogenic isoforms of the p53 family member p73.Semantic proximity Read ↗

p63 and p73: Roles in Development and Tumor FormationSemantic proximity Read ↗

Tumor predisposition in mice mutant for p63 and p73: evidence for broader tumor suppressor functions for the p53 family.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.