Article
Aberrant regulation of transforming growth factor-alpha during the establishment of growth arrest and quiescence of growth factor independent cells.
The Journal of biological chemistry - 10 Apr 1998
Howell G M, Humphrey L E, Awwad R A, Wang D, Koterba A, Periyasamy B, Yang J, Li W, Willson J K, Ziober B L, Coleman K, Carboni J, Lynch M, Brattain M G
Abstract excerpt
Autocrine transforming growth factor alpha (TGFalpha) is an important positive growth effector in malignant cells and plays a significant role in generating the growth factor-independent phenotype associated with malignant progression. However, the molecular mechanisms by which TGFalpha confers a growth advantage in progression is poorly understood. The highly tumorigenic cell line HCT116 up-regulates TGFalpha...
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