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Article

Epitope mapping of the house-dust-mite allergen Der p 2 by means of site-directed mutagenesis.

Allergy - 1 Feb 1998

Hakkaart G A, Aalberse R C, van Ree R

Abstract excerpt

Recombinant Der p 2, expressed in the baker's yeast Saccharomyces cerevisiae, was used as a tool to determine IgE- and monoclonal antibody (mAb)-binding sites on this allergen. For this purpose, mutant molecules were produced by application of site-directed mutagenesis. The amino-acid residues spanning cys21-cys27 and cys73-cys78 were deleted, thus preventing loop formation through disulfide bonds. Charged...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 9534915
DOI: 10.1111/j.1398-9995.1998.tb03865.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Epitope mapping of the house-dust-mite allergen Der p 2 by means of site-directed mutagenesis.PMID 9534915Read ↗

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Immune-reactivity of recombinant isoforms of the major house dust mite allergen Der p 2.Semantic proximity Read ↗

Multiple-mutation at a potential ligand-binding region decreased allergenicity of a mite allergen Der f 2 without disrupting global structure.Semantic proximity Read ↗

Pre-clinical allergenicity assessment of IgE epitope-targeted Der p 2 mutants demonstrate potential as hypoallergenic AIT candidates.Semantic proximity Read ↗

Unlocking the allergenic structure of the major house dust mite allergen der f 2 by elimination of key intramolecular interactions.Semantic proximity Read ↗

An immunogenetic analysis of the T-cell recognition of the major house dust mite allergen Der p 2: identification of high- and low-responder HLA-DQ alleles and localization of T-cell epitopes.Semantic proximity Read ↗

Analysis of human IgE epitope of Der f 2 with anti-Der f 2 mouse monoclonal antibodies.Semantic proximity Read ↗

Identification of an immunodominant region of the major house dust mite allergen Der p 2 presented by common human leucocyte antigen alleles.Semantic proximity Read ↗

Definition of a pool of epitopes that recapitulates the T cell reactivity against major house dust mite allergensSemantic proximity Read ↗

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