Article
Immune-reactivity of recombinant isoforms of the major house dust mite allergen Der p 2.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 Feb 1998
Hakkaart G A, Chapman M D, Aalberse R C, van Ree R
Abstract excerpt
BACKGROUND: Recombinant Der p 2, expressed in yeast, lacked reactivity with 5 monoclonal antibodies against natural Der p 2. OBJECTIVE: The aim of this study was to investigate whether the lack of reactivity with recombinant Der p 2 can be explained by the existence of isoforms. METHODS: By site-...
Topics
- Animals
- Antibodies, Monoclonal
- Antigens, Dermatophagoides
- Dust
- Enzyme-Linked Immunosorbent Assay
- Epitopes
- Genetic Variation
- Glycoproteins
- Humans
- Immunoglobulin E
- Mice
- Mice, Inbred BALB C
- Mites
- Mutagenesis, Site-Directed
- Radioallergosorbent Test
- Recombinant Proteins