Article
An immunogenetic analysis of the T-cell recognition of the major house dust mite allergen Der p 2: identification of high- and low-responder HLA-DQ alleles and localization of T-cell epitopes.
Immunology - 1 Oct 1995
O'Brien R M, Thomas W R, Nicholson I, Lamb J R, Tait B D
Abstract excerpt
Cellular reactivity to Der p 2, a major allergen of the house dust mite (HDM) Dermatophagoides pteronyssinus, was studied in a group of 41 symptomatic HDM sensitive patients, using fresh peripheral blood mononuclear cells (PBMC) and assays of proliferation. Sixty per cent of the patients responded to Der p2, with reactivities being greater in patients with asthma as one of their clinical manifestations and also...
Topics
- Adolescent
- Adult
- Alleles
- Allergens
- Animals
- Antigens, Dermatophagoides
- Cell Division
- Child
- Epitopes
- Glycoproteins
- HLA-DQ Antigens