Article
Epitope-Specific Binder Design by Yeast Surface Display.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2015
Mann Jasdeep K, Park Sheldon
Abstract excerpt
Yeast surface display is commonly used to engineer affinity and design novel molecular interaction. By alternating positive and negative selections, yeast display can be used to engineer binders that specifically interact with the target protein at a defined site. Epitope-specific binders can be useful as inhibitors if they bind the target molecule at functionally important sites. Therefore, an efficient method...
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