Article
Effects of double mutation at two distant IgE-binding sites in the three-dimensional structure of the major house dust mite allergen Der f 2 on IgE-binding and histamine-releasing activity.
Bioscience, biotechnology, and biochemistry - 1 Jul 2001
Takai T, Hatanaka H, Ichikawa S, Yokota T, Inagaki F, Okumura Y
Abstract excerpt
Recently, we reported that introduction of mutations that induced conformational changes of the major mite allergen Der f 2 was an efficient strategy to reduce the allergenicity for safer allergen-specific immunotherapy. In this study, we evaluated another strategy, disruption of two independent IgE epitopes without inducing conformational change. We analyzed allergenicities of the wild-type Der f 2, two single...
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