Article
Rapid apolipoprotein E genotyping from mailed buccal swabs.
Journal of neuroscience methods - 31 Jan 1998
Ilveskoski E, Lehtimäki T, Erkinjuntti T, Koivula T, Karhunen P J
Abstract excerpt
Genetic polymorphism of apolipoprotein E (apoE) is linked with the risk of cardiovascular and Alzheimer's disease (AD). We determined apoE genotypes from mailed buccal cell swabs in 36 healthy individuals and 18 demented patients suffering from AD. DNA was released from the swabs by a rapid lysis technique. Polymerase chain reaction using 'hot start' and restriction enzyme digestion by HhaI was used for...
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