Article
Down-regulation of platelet endothelial cell adhesion molecule-1 results in thrombospondin-1 expression and concerted regulation of endothelial cell phenotype.
Molecular biology of the cell - 1 Apr 1998
Sheibani N, Frazier W A
Abstract excerpt
bEND.3 cells are polyoma middle T-transformed mouse brain endothelial cells that express very little or no thrombospondin-1, a natural inhibitor of angiogenesis, but express high levels of platelet endothelial cell adhesion molecule-1 (PECAM-1) that localizes to sites of cell-cell contact. Here,...
Topics
- Animals
- Brain
- CD36 Antigens
- Carcinogenicity Tests
- Cell Adhesion
- Cell Communication
- Cells, Cultured
- Down-Regulation
- Endothelium
- Male
- Mice
- Mice, Nude
- Neovascularization, Physiologic
- Oligonucleotides, Antisense
- Phenotype
- Platelet Endothelial Cell Adhesion Molecule-1
- Thrombospondin 1
- Transfection